Investor Presentaiton

EXECUTIVE SUMMARY ■ Net income of $406.4 million, diluted earnings per common share of $1.91 ▪ Return on average common equity of 14.5% ■ The current quarter included: ◉ $6.1 million pre-tax severance-related charges $3.4 million pre-tax pension settlement related charge $13.0 million pre-tax gain relating to property sales Net one-time tax benefits of $13.9 million primarily relating to a lower net tax impact from international operations Key Macroeconomic Factors 4Q21 End of Period Month Lag1 Quarter Lag² YOY Seq YOY Seq YOY Seq S&P 500 26.9% 10.6% 31.5% 2.0% 28.1% 0.2% MSCI EAFE Local 16.1% 3.6% 23.2% 0.3% 24.4% 0.7% 1 month Libor (Avg) (5) bps - bps 3 month Libor (Avg) (5) bps 5 bps EUR/USD GBP/USD 7.6% 0.9% 1.9% (0.5)% 1 Month Lag YoY represents the average month-ends of Sept. 2021 - Nov. 2021 vs. Sept. 2020 - Nov. 2020. Month Lag Seq represents the average month-ends of Sept. 2021 - Nov. 2021 vs. Jun. 2021 - Aug. 2021. 2 Quarter Lag YoY represents quarter-end Sept. 2021 vs. Sept. 2020. Quarter Lag Seq represents quarter-end Sept. 2021 vs. Jun. 2021. northerntrust.com | 2022 Northern Trust 2

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