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Investor Presentaiton

Daiichi-Sankyo ENHERTU Performance in Each Region (US, EU) Steady increase in product sales due to market penetration and additional indication Global product sales: FY2022 Q1 results 31.3 Bn JPY (YOY +18.4 Bn JPY) FY2022 forecast 128.4 Bn JPY (YOY +63.0 Bn JPY) US Product sales: FY2022 Q1 results 20.0 Bn JPY (155 Mn USD) FY2022 forecast 83.1 Bn JPY (639 Mn USD) Indication: HER2+ BC 2L/3L, HER2+ GC 2L Market share status HER2+ BC 3L: Maintaining No.1 new patient share HER2+ BC 2L: Achieving No.1 new patient share already HER2+ GC 2L: Achieving No.1 new patient share Other progress ➤ Approved for HER2+ BC 2L and started promotion (May 2022) Classified as a category 1 preferred regimen for patients with tumors that are HER2 IHC 1+ or 2+ and ISH negative in NCCN*1 guidelines (Jun. 2022) Europe Product sales: FY2022 Q1 results 6.7 Bn JPY (52 Mn USD) FY2022 forecast 23.0 Bn JPY (177 Mn USD) Indication: HER2+ BC 2L/3L Market share status HER2+ BC 3L: Maintaining No.1 new patient share (UK, France, Germany) Other progress Approved for HER2+ BC 2L and started promotion (Jul. 2022) ENHERTU® trastuzumab deruxtecan *1 NCCN: National Comprehensive Cancer Network 12
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