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Reimagining Medicine

Company overview Financial review 2023 priorities Appendix PluvictoⓇ rapid uptake in US reflects very strong demand, driven by significant unmet need and impressive clinical profile Sales evolution Global sales, USD m 80 60 179 2 Q1 10 10 Q2 Q3 Q4 2022 NBRX new to brand prescriptions. mCRPC metastatic castration-resistant prostate cancer. 31 Investor Relations | Q4 2022 Results GROWTH PLUVICTO FY sales USD 271 million (almost entirely US) NBRx share 18% in post-taxane mCRPC 160+ unique accounts in US treated with Pluvicto in 2022 More than 75% of insured lives covered (across Medicare, Medicaid and private payers) Permanent A code effective in October Approved in EU for mCRPC post-taxane NOVARTIS | Reimagining Medicine
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