Calliditas Therapeutics IPO Presentation Deck
Disease origin and progression - predominant theory
IgA-dependent
immune complex
Liver
Peyer's patches
Gallbladder
Peyer's Patches-
Follicles of lymphatic
tissue, known as Peyer's
patches, in the distal part
of the small intestine
(ileum) produce
secretory IgA antibodies
Galactose-deficient IgA
Patients with IgAN have
an increased appearance
in the blood of secretory
IgA antibodies that lack
galactose units
(galactose-deficient IgA)
in the hinge region,
which makes the
antibody immunogenic
Immune recognition
These IgA antibodies
trigger autoantigen
production and form
autoantibody complexes
with autoantibodies
directed against the IgA
hinge region
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These aggregates form
pathogenic immune
complexes that deposit in
the glomeruli, which are
the filtration apparatus of
the kidney
Source: Suzuki et al, J Am Soc Nephrol 2011;22(10):1795-803; Novak et al, Curr Opin Nephrol Hypertens 2013; 22(3):287-94; Novak et al, Kidney Dis (Basel). 2015; 1(1):8-18
calliditas
4
IgA Nephropathy
The deposits of immune
complexes in the glomeruli
cause an inflammatory
cascade that destroys the
glomeruli, reducing the
kidney's ability to remove
waste products from the
blood and eventually may
result in ESRD
June 2020
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