BioNTech Investor Day Presentation Deck
Endolysins are highly potent and allow laser-focused microbiome modulation
Pathogenic bacteria¹
G.
swidsinskii
CFU/ml
Method: Bacteria grown in vitro
and then treated with single dose
of PM-477 for 5 hours. Suspension
plated and CFU evaluated
quantitatively on a log₁0 scale
10⁹.
108.
107-
106-
105.
104-
103.
102.
G.
vaginalis
> 100,000x
reduction
Untreated
Treated
G.
leopoldii
Untreated
Treated
PM-477
0.03-1
Untreated
Treated
40 µg/ml
LOD
CFU/ml
10⁹
108.
107-
106-
105.
104-
103-
102,
MIC, minimum inhibitory concentration
1 Landlinger C, et al. Pathogens 2021; 10:54; 2 Landlinger C, et al. Antimicrob Agents Chemother 2022; 66:e0231921.
L.
crispatus
ooo
Beneficial bacteria
Untreated
Treated
L.
L.
L.
gasseri jensenii rhamnosus
مهم
Untreated
Treated
معم
MIC range (µg/ml) for Gardnerella (>20 strains tested)²
Clindamycin
<0.06-1
Untreated
Treated
Untreated
Metronidazole
8 to 128 (R)
Treated
256
μg/ml
LOD
PM-477 with low MIC (0.1-1 µg/ml) for Gardnerella
Lactobacilli grow in the presence of high doses of PM-477 (MIC >256 µg/ml)
Antibacterials
-60% of strains resistant
to metronidazole (MDZ)
FOR
BIONTECH
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