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Target DNA Non-homologous end joining Site-specific DNA break Nucleotide deletion Cas9 Nucleotide insertion Gene disruption Point mutation ORNA CRISPR WAS MEANT FOR MORE THAN CUTTING Corrected nuclectide PAM sequence Homology-directed repair Donor DNA Precise Repair Science RNA-Guided Human Genome Engineering via Cas9 Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville and George M. Church 15 FEBRUARY 2013 VOL 339 SCIENCE www.sciencemag.org O

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