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Investor Presentaiton

Top-tier talent Differentiated process Scalable platform Successful history of investing in development-stage therapies Robust development-stage portfolio Invested $8bn in development-stage therapies since 2012 ☐ Require strong proof of concept data Broad landscape of opportunities Not constrained by therapeutic area Target returns in the teens • 10 development-stage therapies currently in portfolio History of identifying therapies with unmet and underserved patient needs Development-stage investments Royalty Pharma approval success rate (2) (by primary disease area(1)) Hypertrophic cardiomyopathy Multiple sclerosis Solid tumors Myelofibrosis Rheumatoid arthritis Alzheimer's disease Depression Paroxysmal nocturnal hemoglobinuria Spinal muscle atrophy Migraine Leukemia Cystic fibrosis Diabetes Breast cancer Heart failure Asthma Inflammatory disease 95% 79% By number of investments By value of investments 1. ROYALTY PHARMA 2. Split reflects the number of development-stage royalty acquisitions by primary disease area from 2012 through Q1 2022. Approval success rate defined as any development-stage royalty acquisition that has received a regulatory decision on approval. Therapies not approved include investments in vosaroxin, palbociclib and Merck KGaA's anti-IL17 nanobody M1095. 89 63
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