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Reimagining Medicine

Company overview Financial review 2023 priorities Appendix Sandoz 2023 and mid-term guidance Expected, barring unforeseen events; growth vs. PY in cc 2023 Mid-term Sales expected to grow low-to-mid single digit Core Oplnc expected to decline low double digit, reflecting required stand-up investments to transition Sandoz to a separate company and continued inflationary pressures Sales expected to grow low-to-mid single digit CAGR Core Oplnc margin expected to expand to mid 20s, continuously progressing from the low 2023 base driven by continued Sales growth and operational efficiencies Key assumptions: We continue to expect that the planned Sandoz spin-off is completed in H2 2023 Note: after completion of planned Sandoz spin-off, Core Oplnc guidance will be expressed in terms of core EBITDA. 42 Investor Relations | Q4 2022 Results FINANCIAL PROFILE 1 NOVARTIS | Reimagining Medicine
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