Investor Presentation Q1 2023

73 Investor presentation First three months of 2023 Haemophilia is a rare disease with severe unmet medical needs but the market is highly competitive Recombinant haemophilia product sales DKK billion 50 50 40 30 20 10 0 -0.1% +15% +31% Novo NordiskⓇ 2018 2022 2018 2022 2018 2022 Haemophilia with inhibitors Haemophilia A Haemophilia B Patients1 ~ 7,000 ~ 185,000 ~ 38,000 NovoSevenⓇ susoctocog alfa² Coagil³ Feiba4 Hemlibra NovoEight® EsperoctⓇ Eloctate Xyntha/Refacto Helixate/Afstyla Benefix Kogenate/Kovaltry/Jivi Advate/Adynovate Hemlibra Alprolix Idelvion RefixiaⓇ/RebinynⓇ Rixubis 1 Total diagnosed patients in segment, WFH annual survey 2021 (numbers may be understated as 118 out of 147 countries responded); 2 Obizur only indicated for acquired haemophilia; 3 Plasma-derived; 4 Part of the Hemlibra sales is used for treatment of haemophilia A patients in 2021 Source: Company reported sales and Evaluate Pharma

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