Investor Presentaiton

TLX591 patient experience Off-target irradiation - quality of life matters TLX591 Antibodies are functionally specific for tumour-expressed PSMA and do not "hit" most endogenous PSMA expression Liver (preferred clearance organ) Fecal excretion For personal use only Data courtesy of Prof. Neil Bander, WCMC. Telix Pharmaceuticals Limited (ASX: TLX) TELIX PHARMACEUTICALS Lacrimal, Parotid, Submandibular (salivary) glands Spleen, Liver Kidneys, Small bowel Bladder (urinary excretion) Small molecule Small molecule radioligands taken up by endogenous PSMA Additional off-target effects with small molecule radioligands (not experienced with TLX591): Dry eye Xerostomia Back pain from ganglia irradiation 34

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