Investor Presentation Full Year 2021

100 Investor presentation Full year 2021 GLP-1 market share and market growth in EMEA 80% 50% 20% -10% GLP-1 market growth and Novo Nordisk market share -40% Nov 2018 NN market share Market growth (right axis) GLP-1 market size and growth EMEA 60% 69% DKK billion -31% 1 18 3 0 58% 14 39% 40% 31% 20% 55% -39% 58% 0% Nov 2021 Nov 2020 Novo Nordisk Eli Lilly Others Nov 2021 -NN share of growth Novo Nordisk Competitors NN growth (right axis) Source: IQVIA, Nov 2021, Value, MAT, EMEA: Europe, Middle East and Africa; NN: Novo Nordisk

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