Investor Presentaiton

LOVVOLUS DURATION JEUVEAU EXTRA-STRENGTH PHASE II DURATION STUDY De KAPLAN-MEIER: GLOBAL AESTHETIC IMPROVEMENT RETURN TO BASELINE (IMPROVED, MUCH IMPROVED) Investigator assessment. PERCENT OF PATIENTS (%) 100- 80 60 40 20 PRABOTULINUM ES 40U 183 (153, 211) DAYS, 26.1 WEEKS, 6.0 MONTHS PRABOTULINUM 20U 149 (130, 174) DAYS, 21.3 WEEKS, 4.9 MONTHS ONABOTULINUM 20U 148 (121, 174) DAYS, 21.1 WEEKS, 4.9 MONTHS 30 60 90 120 (95% CLS]): 150 PRA 40U VS. PRA 20U: HR 2.096, P-VALUE 0.0006 PRA 40U VS. ONA 20U: HR 2.39, P-VALUE 0.0002 180 210 240 270 300 330 DAYS FROM TREATMENT 23

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