Pharma Update

Levers to drive R&D excellence were identified E.g., go/no go decisions based on critical review of scientific and commercial risk E.g., leverage RWD and Al to increase research output and focus on clinical stage external innovation E.g., focus on assets with best-in- disease and first-in-class potential, manage portfolio value mix Success rate ✓ Volume R&D productivity Costs ✓ Cycle time E.g., simplify processes, deploy industry-leading. data systems and operational excellence RWD-real-world data; Al-artificial intelligence Value Effectiveness Efficiency E.g., reduce white space between clinical phases, increase speed in development, leverage technology & culture change Roche 28

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