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Conditions treated 11 Humira Crohn's disease, ulcerative Figure 10: CCOs spent more on Humira than any other drug at pharmacies in 2021 Brand name(s) Amount $53 million Claims 7,991 colitis, plaque psoriasis Biktarvy HIV Mavyret Hepatitis C Lantus, Basaglar Diabetes 8,178 $29 million 2,072 $27 million 71,038 $26 million Kwickpen, Toujeo Trikafta Cystic fibrosis 912 $22 million Stelara Crohn's disease, ulcerative 947 $20 million colitis, plaque psoriasis Trulicity Type 2 diabetes 21,249 $18 million Enbrel Plaque psoriasis, rheumatoid, 2,626 $15 million and psoriatic arthritis Eliquis Humalog Deep vein thrombosis 27,757 $14 million Type 2 diabetes 42,706 $13 million Source: OHA, the Food and Drug Administration, and Drugs.com The average cost per prescription for more expensive drugs in Figure 10 ranges from $300 to $24,000. Conversely, the most dispensed drugs — like albuterol sulfate, omeprazole, and ibuprofen - have an average cost per prescription of $3 to $35. Understanding the true cost of prescription drugs is difficult. Costs are often obscured by nondisclosure agreements throughout the distribution chain. For example, wholesale acquisition cost is the drug manufacturer's list price to wholesalers; however, this is typically not the actual price paid. The average wholesale price is the published list price for drugs sold by wholesalers to retail pharmacies and is used as a starting point for negotiations. Drug cost inputs are not always available and determining actual prices paid is difficult without access to confidential information. Many negotiated drug prices are proprietary and known only to the parties involved in the transaction. Drug manufacturers do not provide public information on how they set the list price and have often not been required to explain changes in a drug's list price. 12 PBMs add an additional layer of complexity, as the prices paid to drug manufacturers and reimbursements to pharmacies are also considered proprietary information. States are required to invoice manufacturers for rebates on covered drugs for Medicaid. OHA has full visibility of the net cost of drugs under FFS, but not in coordinated care. While increased transparency in prescription drug prices may not directly lower costs, it will help policymakers better understand which prescription drugs and which portions of the supply chain are cost drivers. Oregon has placed an emphasis on drug manufacturers, but PBMs have received less scrutiny In 2018, the Oregon Legislature enacted the Prescription Drug Price Transparency Act. Housed in the Department of Consumer and Business Services (DCBS), the act established the Task Force on Fair 11 Other conditions may be treated with these medications. 12 House Bill 2658 requires drug manufacturers to report to DCBS specific information on price increases for certain medications. Oregon Secretary of State | Report 2023-25 | August 2023 page 11
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