Q4 2022 Results
Company overview
Innovation: Pipeline overview
Cardiovascular
Ophthalmology
Financial review
Immunology
cipargamin - PfATP4 inhibitor
NCT04675931 KARISMA (CKAE609B12201)
Indication
Malaria severe
Phase 2
Phase
Patients
252
2023 priorities
Innovation: Clinical trials
Primary
Outcome
Measures
Arms
Intervention
Target
Patients
Percentage of participants achieving at least 90% reduction in Plasmodium
falciparum (P. falciparum) at 12 hours [ Time Frame: Day 1 (12 Hours) ]
Arm 1: experimental, IV KAE609 Dose regimen 1
Arm 2: experimental, IV KAE609 Dose regimen 2
Arm 3: experimental, IV KAE609 Dose regimen 3
Arm 4: active comparator, IV Artesunate
Arm 5: Coartem, Standard of care
Patients with Malaria, severe
Readout
Milestone(s)
2024
Publication
TBD
Neuroscience
Global Health
Appendix
Abbreviations
Oncology
Other
Biosimilars
101 Investor Relations | Q4 2022 Results
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