Investor Presentaiton

Laboratory testing algorithm T. pallidum Total Antibody Screen Syphilis RPR TPPA screen Negative n/a n/a Reactive Non-Reactive¹ Reactive Reactive n/a RPR Interpretation No serologic evidence of past or current syphilis infection. In the setting of recent exposure, or signs/symptoms of primary syphilis, repeat testing in 2 to 4 weeks. Consistent with syphilis infection. Clinical manifestations and treatment history is required to refine interpretation: i) Infectious syphilis (primary, secondary or early latent) ii) Late latent syphilis iii) Tertiary syphilis iv) Treated syphilis with persistent reactive RPR No serologic evidence of past or current syphilis infection. Screening test is most likely falsely reactive. Indeterminate Syphilis serology is inconclusive. Recommend repeat testing in 2 to 4 weeks. Consistent with syphilis infection. Clinical manifestations and treatment history is required to refine interpretation Reactive Non-Reactive Non-Reactive Reactive² Non-Reactive Reactive Non-Reactive Reactive Non-Reactive T. pallidum particle agglutination (TPPA) Reactive (or Repeat Reactive) Non-Reactive³ Indeterminate Reactive5 (or Repeat Reactive) Source: Syphilis testing algorithm: https://rrpl- testviewer.ehealthsask.ca/SCI/What%20is%20new%20at%20SDCL/Syphilis%20Algorithm%20Interpretation%20v3.1.pdf + Saskatchewan Health Authority

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