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Pharma Update

Holistic, end-to-end analysis of our R&D productivity Commitment to delivering the worlds most impactful medicines • Success rate ✓ Volume ✓ Value Effectiveness R&D productivity = Costs Cycle time } Efficiency Holistic and end-to-end Teams from early to late stage development, and commercial involved 'Leave no stone unturned' analysis RWD-real-world data; AI/ML-artificial intelligence/machine learning ☐ Strong base Ability to capitalize on significant past investments, for example: . Breadth of disease area talent . Computational biology expertise Platform technologies ☑» New opportunities RWD and Al/ML, computational biology and advanced analytics . Application of new technologies in R&D Institute of Human Biology (IHB) Roche 22
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