Q4 2022 Results
Company overview
Innovation: Pipeline overview
Cardiovascular
Financial review
Immunology
MayzentⓇ - S1P1,5 receptor modulator
NCT04926818 NEOS (CBAF312D2301)
Indication
Phase
Multiple sclerosis, pediatrics
Phase 3
Patients
180
Primary
Outcome
Annualized relapse rate (ARR) in target pediatric participants
2023 priorities
Innovation: Clinical trials
Neuroscience
Measures
Arms
Intervention
Target
Patients
Readout
Milestone(s)
Arm 1: Experimental ofatumumab - 20 mg injection/ placebo
Arm 2: Experimental siponimod - 0.5 mg, 1 mg or 2 mg/ placebo
Arm 3: Active Comparator fingolimod - 0.5 mg or 0.25 mg/ placebo
Children/adolescent patients aged 10-17 years old with Multiple Sclerosis (MS).
The targeted enrollment is 180 participants with multiple sclerosis which will
include at least 5 participants with body weight (BW) ≤40 kg and at least 5
participants with age 10 to 12 years in each of the ofatumumab and siponimod
arms. There is a minimum 6 month follow up period for all participants (core
and extension). Total duration of the study could be up to 7 years.
2026
Publication
TBD
77 Investor Relations | Q4 2022 Results
Oncology
Appendix
Abbreviations
Other
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