ALBRIOZA Commercial Launch
AMX0035 - Designed to Reduce Neuronal Cell Death
AMX0035: Dual UPR,
mitochondrial
apoptosis targeting
Reduces ER dependent
death
Reduces Mito
MOTOR NEURON
dependent death
MICROGLIAL CELL
Neuroinflammation
(inflammatory cytokine
release, immune
cell infiltration)
Glutamate
excitotoxicity
Oxidative
stress
Impaired crosstalk
and calcium
dysregulation
ER stress
Mitochondrial
dysfunction
N
Unfolded protein
Apoptosis
response
Misfolded and
aggregated protein
(SOD1, FUS, TDP-43)
Cell injury and death
NUCLEUS
Aberrant transcription,
mRNA processing,
and transport
CYTOPLASM
MOA of AMX0035 in ALS is unknown
Zhou W. J Biol Chem. 2011;286(17):14941-14951.; Rodrigues CM, Steer CJ. Expert Opin Investig Drugs. 2001;10(7):1243-1253.; Rodrigues CM, et al. Biochemistry. 2003;42(10):3070-
3080.; Fels JA, et al. Ann Clin Transl Neurol. 2022. doi.org/10.1002/acn3.51648.
The mechanism of action is unknown
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