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argenx SE Investor Day Presentation Deck

Albumin Serves a Crucial Role in Lipid Housekeeping Proposed Interactions Between Serum Albumin and CV Outcomes4 Underlying conditions argenx Inflammatory process Vasodilatory ability ↓ G Low serum albumin levels Vascular permeability ↑ Anticoagulation ↓ Cholesterol transport and LDL catabolism Adverse cardiovascular events Small molecule binding ↓ (toxins & medicines) Serum albumin is proposed to enhance cholesterol transport, facilitating steady state levels as cholesterol is metabolized (1) Law S, et al. Int J Mol Sci. 2019; (2) Packard CJ, et al. J Lipid Res. 2000; Noto D. et al., Kidney International. 1999; (4) Chien SC, et al. Biomark Res. 2017; (5) Sankaranarayanan S, et al. J Lipid Res. 2013 20

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