Investor Presentation First Nine Months of 2022 slide image

Investor Presentation First Nine Months of 2022

64 Investor presentation First nine months of 2022 Novo NordiskⓇ Across the STEP 1, 3, and 4 trials, a weight loss of 16.9% to 18.2% was reported for people treated with semaglutide 2.4 mg STEP 1 Weight management Baseline body weight 105.3 Change from baseline in BW (%) STEP 3 Weight mgmt. STEP 4 Sustained weight management with IBT After 68 weeks 105.8 107.2 STEP 5 Weight loss over 2 years STEP 2 Weight mgmt. with T2D STEP 8 Head-to-head trial versus liraglutide 3.0 mg After 20 weeks 96.1 106.0 99.8 104.5 Sema Placebo Sema IBT Sema Placebo Sema + IBT Placebo Sema 6.5 Placebo Sema Placebo Sema Lira 3.0 mg Placebo -2 -4 8 6420246% -2.4 -6 -5.0 -5.2 -8 -10 -8.8 -12 -14 -16 -18 * -16.9' -17.6* -18.2* -16.7 -0.6 -3.1 -6.6 * P-value <0.0001, based on the trial product estimand (secondary statistical approach): treatment effect if all people adhered to treatment and did not initiate other anti-obesity therapies IBT: Intensive behavioural therapy; Sema: Semaglutide; Lira: Liraglutide; BW: Body weight; T2D: Type 2 diabetes; Mgmt.: Management -10.6 * -17.1 * -1.8
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