1Q21 Investor Update slide image

1Q21 Investor Update

22ND CENTURY INVESTMENT HIGHLIGHTS +$1.3T global addressable market across tobaccco¹, hemp/cannabis², & third plant-based franchise³ ▪ VLN® is the first and only reduced nicotine content cigarette anticipating FDA's Modified Risk Tobacco Product (MRTP)4 designation ▪ Fully prepared to launch VLN® within 90 days of authorization; designation is a catalyst for VLNⓇ brand and tobacco franchise opportunities ▪ Developing new disruptive, proprietary hemp/cannabis plant lines with stable, higher yields, and other commercially desirable traits through accelerated breeding processes ▪ Potential legislative tailwinds including enactment of reduced nicotine mandate and legalization of cannabis would open tremendous revenue opportunities Clear growth strategy with continuous, rich pipeline of revenue opportunities ■ Exclusive, pure-play plant biotechnology core competencies Creating disruptive, proprietary commercial plant lines and new intellectual property in tobacco, hemp/cannabis, and other large adjacent market ▪ Over 200 issued and pending patents in plant-based biotechnology applications supports entry into adjacent high-value markets. ▪ 20+ years of expertise in developing new, disruptive technologies 1. Foundation for a Smoke Free World; https://www.smokefreeworld.org/wp-content/uploads/2019/08/FSFW Global-Trends-in-Nicotine 6.22.2020.pdf 2. Prohibition Partners; "The Global Cannabis Report - November 2019" 3. Addressable market of third plant-based franchise is based on a global estimate in 2019. 4. Modified Risk Tobacco Product; https://www.fda.gov/tobacco-products/advertising-and-promotion/modified-risk-tobacco-products Financial strength ▪ Efficient operating model with multiple routes to market - commercialization, licensing, and partnership opportunities ▪ Clear path to profitability through existing platforms, cultivating large adjacent markets to leverage core technologies for additional growth ▪ Healthy balance sheet with more than $30M in cash, including $11.8M additional cash received from warrants exercised in Feb/March 2021 22nd Century Group, Inc. 16
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