Ocuphire Pharma Investor Update

RM Mean Pupil Diameter (mm) 00 22 A p<0.0001 p<0.0001 p<0.0001 Max dilation; Treatment CO 4 Mean Pupil Diameter Over Time by Eye Color Nyxol Reduced Pupil Diameter Rapidly in Both Light and Dark Irides Mydriatic 3 -1 Mean Pupil Diameter - Light Irides 0 0.5 1 HA p<0.0001 p<0.0001 Placebo (n=58) -Nyxol (n=113) p<0.0001 1.5 2 3 4 5 Time Post-Treatment with Nyxol/Placebo MIRA-3 Phase 3 Trial Mean PD - Study Eye (mITT) # p=0.0007 6 24 9 8 4 3 Mydriatic -1 p<0.0001 Max dilation; Treatment p<0.0001 Mean Pupil Diameter - Dark Irides 0 0.5 Source MIRA-3 Table 14.2.2.5-(mITT). The p-values are change from max pupil dilation treatment compared to placebo. Data includes all three mydriatics (Phenylephrine, Tropicamide, Paremyd). Standard Error bars are shown. 1 p<0.0001 p<0.0001 p<0.0001 Placebo (n=66) -Nyxol (n=131) p<0.0001 3 4 5 1.5 2 Time Post-Treatment with Nyxol/Placebo 6 p<0.0001 24 Ocuphire PHARMA

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