American Thoracic Society - Sanofi Investor Call

Microbes COPD Endotypes: "Type 2 High" Eosinophil Predominant T2 Viruses Smoke/pollutants Neutrophil Predominant T1 & T17 Smoke/pollutants Viruses Airway epithelium Microbes Mast cell Goblet cell Goblet cell Dendritic cell IL-4 IL-33 TSLP Macrophage IL25 TSLP тно Dendritic cell THO IL-13 IL-5 IL-5 IL-13 Tc1 IL-1, IL-8, TNF-α IL-25 IL-23 ILC3 B cells Mast cell TH2 IL-13 ILC2 Eosinophils IL-13 Neutrophils TH1/T17 Present in 20 to 40% of COPD ATS 2023 Airway smooth muscle Majority of COPD 17 12

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