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Investor Presentaiton

Major R&D Milestones (5DXd-ADCS 2) Project Target Indication [phase, study name] NSCLC • 2/3L [Ph3, TROPION-Lung01] Dato-DXd BC • HR+ and HER2 low or negative BC, 2/3L [Ph3, TROPION-Breast01] • TNBC, 1L HER3-DXd NSCLC [Ph3, TROPION-Breast02] • EGFR mutated, 2L [Ph3, HERTHENA-Lung02] DS-7300 (I-DXd) SCLC . 2L [Dose optimization, Ph2] As of Jul 2023 FY2023 FY2024 H1 H2 • TLR obtained • TLR anticipated TLR anticipated TLR anticipated . ⚫ TLR anticipated Daiichi-Sankyo Bold: update from FY2022 Q4 BC: breast cancer, HR: hormone receptor, NSCLC: non-small cell lung cancer, SCLC: small cell lung cancer, TLR: top line results, TNBC: triple-negative breast cancer Timeline indicated is based on the current forecast and subject to change 33
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