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Novo Nordisk Annual Report 2023 Introducing Novo Nordisk Strategic Aspirations Risks Management Consolidated statements Additional information DIABETES VALUE MARKET SHARE (%) ... GLP-1 -- Insulin -Total diabetes 60 54.9% 54.8% 52.7% 50.4% 50 44.3% 43.8% 44.6% 43.9% 40 33.8% 31.9% 29.3% 30.1% 30 20 2020 2021 2022 2023 Source: IQVIA MAT, Nov 2023. DIABETES SALES (DKK billion) 200 Sales as reported Growth at CER 14% 160 13% 8% 120 80 40 29% 0 2020 2021 2022 2023 DIABETES Strengthening diabetes leadership with strong GLP-1-based product growth We have extended our leadership in diabetes care and increased our value market share by 1.9 percentage points to 33.8% in 2023, fuelled by strong uptake of the GLP-1-based products OzempicⓇ and Rybelsus® in both North America and International Operations. OzempicⓇ is now the world's biggest-selling diabetes medicine. Available as a once-weekly injection, it is contributing to a major shift in treatment for type 2 diabetes. At the same time, our oral GLP-1-based therapy, Rybelsus®, is gaining ground by offering patients with type 2 diabetes an intervention without injections. Demand for these two products has grown to unprecedented levels, helping to generate record sales growth despite supply constraints and a decline in demand for the first-generation GLP-1-based product VictozaⓇ. Although competition is increasing, Novo Nordisk remains the market leader in the GLP-1 market with a value share of 54.8%, broadly steady compared to 2022 where our value share stood at 54.9%. The high demand for our GLP-1-based medicines is partly fuelled by a growing understanding of the importance of the class among healthcare professionals, patients and payers. This includes a recognition that certain GLP-1-based therapies are not only highly effective options for controlling blood sugar levels, but may also offer significant benefits in terms of reducing weight and cardiovascular risks - positive effects now reflected in international treatment guidelines. Despite declining sales of insulin in key markets, reflecting both pricing pressures and lower volumes in some geographies, Novo Nordisk's insulin value market share remains little changed from 12 months earlier, at 43.9%, compared to 44.6% in 2022. Across International Operations, insulin is still an important and growing segment, although insulin sales in China have been adversely impacted since the introduction of Volume Based Procurement in mid-2022. The US has also experienced a decline in overall volumes and a decrease in realised prices due to channel/payer mix and higher rebates. Nevertheless, in a global diabetes market driven by high GLP-1 growth, we are uniquely positioned to maintain and strengthen our leadership in this sector and have already met our target of securing value market share of at least one-third by 2025. 31 31
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