Reimagining Medicine Q2 2023 Results slide image

Reimagining Medicine Q2 2023 Results

Company overview Financial review Conclusions Appendix References Key 2023 readouts for high-value medicines on track INNOVATION Key assets* with submission enabling readouts in 2023 KisqaliⓇ Ph3 NATALEE trial in adjuvant breast cancer testing broad patient population (anatomical stage II and III1), further Primary endpoint met at interim analysis follow up data on track for H2 2023 EMA and FDA regulatory submission PluvictoⓇ PSMAfore trial in mCRPC (post-ARDT, pre-taxane) positive readout; detailed data presentation planned in Q4 2023 FDA regulatory submission planned in Q4 2023 Iptacopan PNH filed with FDA and EMA in Q2 2023 APPLAUSE-IgAN Ph3 readout² planned in Q4 2023 APPEAR-C3G Ph3 readout planned in Q4 2023 expected Q3/Q4 2023 *Unprobabilized peak sales of all asset indications in late-stage development: > USD 1bn > USD 2bn > USD 3bn mCRPC metastatic castration resistant prostate cancer. ARDT-androgen receptor directed therapy. 1. Based on AJCC prognostic staging. 2. 9 months analysis potentially supporting US Subpart H filing. 15 Investor Relations | Q2 2023 Results ✓ NOVARTIS | Reimagining Medicine
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