Investor Presentaiton
Wave 2
CD19 NEX T to reset the immune system in multiple
Immunology indications
Transformational potential
Sequential immunotherapy offers the potential for a
functional cure in autoimmunity: 1: Control
inflammation; 2: Reset immune memory; 3: Promote
homeostasis and repair
Academic study
Causal human biology
20
Before CAR-T
After CAR-T
20
of CD19 CAR-T
demonstrates B
cell memory
reset and
functional cure in
SLE.
Ill Bristol Myers Squibb™
SLEDAI
(disease activity)
15
15
10
T
5
Complete
Remission
•
0
■Pt. 1 ■Pt. 2 ■Pt. 3 Pt. 4 Pt. 5 Pt. 6 ■Pt. 7
Adapted from Taubmann, J., et al EULAR (2023): 93-94
•
Matching modality to mechanism
Single CAR
binder
Chimeric antigen receptor
(CAR): CD19 and intracellular
domains same as Breyanzi
Manufacturing: autologous,
single train with shortened
turn-around time, lower
failure rates
Path to clinical proof-of-concept
Expand on findings from academic study in SLE
Monitor biomarker predictors of cell therapy safety
and efficacy
Demonstrate evidence of resetting immune memory
Not for Product Promotional Use
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