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Investor Presentaiton

Patient A: Severity of Unusual Thought Content and Conceptual Disorganization at Baseline and across 11 Months. Prescriber ratings were performed to assess the presence and severity of unusual thought content and conceptual disorganization (COMPASS Clinician Rating Form), which are linked to disturbances in cognition that are commonly associated with psychosis. NOTE: Graph lines are superimposed when severity levels of symptoms are identical. COMPASS Clinician Rating Form (anchor points): 0=Not Present, 1=Very Mild, 2= Mild, 3-Moderate, 4-Moderately Severe, 5=Severe, 6=Extremely Severe. (Source: Nevada NAVIGATE Early Treatment Program for First Episode of Psychosis) 4.5 Patient A: Unusual Thought Content and Conceptual Disorganization, Year 1 Prescriber-ratings: Presence and Severity 4 3.5 3 2.5 2 1.5 1 0.5 Z 0 -0.5 Base- line 10 11 1 mo 2 mos 3 mos 4 mos 5 mos 6 mos 7 mos 8 mos 9 mos mos mos (0) Unusual Thought Content 4 3 4 2 1 1 1 Conceptual Disorganization 1 0 2 2 1 1 2 02 0 0 1 0 0 0
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