Investor Presentation Full Year 2021 slide image

Investor Presentation Full Year 2021

60 Investor presentation Full year 2021 In STEP 1, people treated with semaglutide had a superior weight loss of up to 16.9% The pivotal STEP 1 trial showed greater than 16% weight loss % change in body weight 0 • Data from STEP 1 -2 -4 -6 ≈ 46% Average age 46 Average BMI - 37.9 kg/m² Placebo: -2.4% • 74.1% women -8 -10 -12 -14 -16 -18 Semaglutide: -16.9% -20 0 48 12 16 20 28 36 44 52 60 68 Time since initiation (weeks) Change in body weight in % depicts observed means since time of randomisation; trial product estimand. BMI: body mass index; SF-36: Short Form (36) Health Survey; IWQOL-lite-CT: Impact of Weight on Quality of Life-Lite questionnaire Novo NordiskⓇ Improvements in lipid profiles as well as C-reactive protein Semaglutide improved health-related quality of life as measured by SF-36 and IWQOL-lite-CT
View entire presentation