23andMe Investor Presentation Deck

CD200R1 was Identified as a Promising Anti-Cancer Drug Target with 23andMe's Proprietary Immuno-oncology (I/O) Genetic Signature Immune and autoimmune phenotypes Cancer phenotypes Identified novel immuno-oncology signature around CTLA4. tonsillectomy - 11d- anti tnf_alpha_or_dmards - juvenile_t1d- iqb.dry_skin_frequency - iodine treatment_ever- hypothyroidism - hyperthyroidism - hashimotos - graves - vitiligo- iqb.dandruff frequency- celiac HLA all- psoriasis- rheumatoid arthritis - took_meds_anti_tnf_alpha- signed log(p) thyroid_removed - immunodeficiency- squamous_cell_carcinoma - basal cell carcinoma - actinic_keratosis - non_melanoma_skin_cancer any_skin_cancer- -10 -5 0 5 10 Genetic Variant in CTLA4 linked with multiple phenotypes in the 23andMe database CD200R1 pathway identified as a critical immune checkpoint with our I/O genetic signature CD200R1 Receptor թսոաալ I/O genetic signature shows opposing effects on autoimmune and cancer phenotypes Cancer Cancer Immune CD200 Ligand DOK2 Protein Immune Cancer signed log(p) -10 -5 0 5 10 We discovered that 3 components of the signaling pathway for CD200R1 have a similar genetic signature to other I/O drugs Copyright © 2022 23and Me, Inc. 23and Me 44

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