Investor Presentaiton

Next steps DONESTAⓇ Support NDA filing with FDA Additional Phase 2 studies to support differentiation for treatment of menopause symptoms O O Hair Skin Sexual desire • ESTETROL New indications in women's health IVF implantation - exploratory clinical studies on endometrial thickening New pharmacoecenomic Phase 2 and Phase 4 studies to establish safety of Estetrol (ESTELLEⓇ/DONESTAⓇ) in breast cancer & blood clotting ZORELINE® • 1-month & 3-month formulation studies Mithra Investor Presentation - November 2023

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