First Quarter 2018 Investor Presentation

Investor Presentation First three months of 2018 Slide 25 Global diabetes prevalence is increasing and 629 million people are expected to have diabetes by 2045 Around 10% of all adults globally have diabetes The number of people with diabetes is expected to increase by 48% by 2045 North America Region China Million 800 Region Europe Region J&K Region AAMEO Region LATAM +48% 629 <4% 4-5% 5-7% 7-9% 9-12% > 12% 600 400 200 151 2000 425 2017 2045 Source: Adapted from International Diabetes Federation: Diabetes Atlas 8th Edition 2017 J&K: Japan & Korea; AAMEO: Africa, Asia, Middle-East and Oceania; LATAM: Latin America Source: International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 8th Edition 2017 changing diabetes® novo nordisk

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