Novo Nordisk Annual Report 2021

Contents Introducing Novo Nordisk Strategic Aspirations Key risks Management Consolidated statements Additional information Novo Nordisk Annual Report 2021 7 Our business model How we create value for society Value Climate 43% reduction of CO2 emissions compared to 2019 *** ** 11 Direct suppliers >60,000 = Manufacturing Resources Insights from healthcare experts, patients and partners Expertise from public and private institutions Financial resources Diverse talent Raw materials R&D --- R&D investments DKK 41.9 billion 48,478 employees, of whom 7,580 were new hires in 2021 Distribution Commercial * Number of unique HCPS educated by independent medical education activities supported through educational grants Healthcare professionals trained >950,000* 34.6 million patients reached with our diabetes products Novo Nordisk Foundation and other shareholders DKK 40,964 million paid out via dividends and share buy-backs Sustainable taxpayer DKK 32,593 million total tax contribution > 5 million patients reached via access and affordability initiatives

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