Income Statement Presentation 2023

Currency impact 2022 CHF / USD +2% +4% +4% +4% 0.94 0.95 0.95 0.92 In 2022 impact¹ is (%p): Roche Q1 HY Sep FY 0.90 0.91 0.91 0.91 YTD 0.92 0.92 0.93 0.94 0.98 0.97 0.97 0.96 0.97 0.99 0.97 0.93 Sales -1 0 -1 -1 T Monthly avg fx rates 2022 Average YTD 2022 Average YTD 2021 CHF / EUR Core operating profit 0 -2 -5% -6% -7% -7% Core EPS 0 -3 1.09 1.09 1.09 1.08 1.04 1.03 1.01 1.00 1.04 1.05 1.02 1.02 1.04 1.03 0.99 0.97 0.96 0.98 0.98 0.99 Monthly avg fx rates 2022 Average YTD 2022 Average YTD 2021 1 On group growth rates 2023 currency impact¹ expected (based on 30 December 2022 FX rates): Around -4%p to -6%p on Sales, Core OP & Core EPS 66

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