Investor Presentation Full Year 2021 slide image

Investor Presentation Full Year 2021

71 Investor presentation Full year 2021 Haemophilia is a rare disease with severe unmet medical needs and the market is highly competitive Number of Low diagnosis and treatment rates people (000) 500 400 300 200 100 0 People with haemophilia within haemophilia Diagnosed Haemophilia A ■Haemophilia B DKK Sales of recombinant haemophilia products billion 40 30 30 20 20 10 Novo NordiskⓇ 0 Inhibitor 2016 2020 2016 2020 2016 Haemophilia with inhibitors NovoSevenⓇ Coagil VII Obizur¹ Haemophilia A EsperoctⓇ NovoEight® 2020 Haemophilia B RefixiaⓇ/RebinynⓇ Idelvion Advate/Adynovate Rixubis Kogenate/Kovaltry/Jivi Feiba² Hemlibra³ Alprolix Xyntha/Refacto Benefix Eloctate/Elocta Helixate/Afstyla Hemlibra Note: The inhibitor segment includes acquired haemophilia patients, patients with low titre inhibitors or with transient inhibitors, and patients on immune tolerance induction. Source: World Federation of Haemophilia (WFH) - Annual survey 2018; WFH: Closing the gap - achieving optimal care, Haemophilia 2012. 1 Obizur only indicated for acquired haemophilia; 2 Plasma-derived; 3 Part of the Hemlibra sales is used for treatment of haemophilia A patients in 2020 Source: Company reported sales and Evaluate
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