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Investor Presentaiton

FY2023 News Flow Planned major publications WCLC (Sep 9-12, 2023) ENHERTU® DESTINY-Lung02: HER2 mutant NSCLC, 2L+, Ph2 • Primary analysis data Dato-DXd TROPION-Lung04: NSCLC w/o AGA, 1L+, Ph1 . Interim data HER3-DXd HERTHENA-Lung01: EGFR mutant NSCLC, 3L, Ph2 •. Primary analysis data DS-7300 (1-DXd) Ph1/2 • SCLC sub-analysis data Regulatory decisions DESTINY-Lung01, 02: HER2 mutant NSCLC, 2L+, Ph2 ENHERTU® • JP: FY2023 Q2 • EU: FY2023 H2 VANFLYTAⓇ QUANTUM-First: AML, 1L, Ph3 • EU: FY2023 H2 Key data readouts ENHERTU® Daiichi-Sankyo As of Jul 2023 DESTINY-Breast06*: HR+ and HER2 low BC, chemo naïve, Ph3 • FY2023 H2 TROPION-Breast01*: HR+ and HER2 low or negative BC, 2/3L, Dato-DXd Ph3 FY2023 H2 DS-5670 COVID-19 mRNA vaccine, original strain, booster vaccination, healthy adults, Ph1/2/3 ⚫ JP: FY2023 Q2 Bold: update from FY2022 Q4 AGA: actionable genomic alterations, AML: acute myeloid leukemia, BC: breast cancer, HR: hormone receptor, NSCLC: non-small cell lung cancer, SCLC: small cell lung cancer, WCLC: World Conference on Lung Cancer Timeline indicated is based on the current forecast and subject to change. *Event-driven study 30 50
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