Half-Year 2022 Financial and Clinical Trials Update

Low currency impact expected in 2022 CHF / USD Average YTD 2022 +2% +4% +4% +4% 0.94 0.95 0.95 0.92 0.90 Average YTD 2021 0.91 0.91 0.91 Roche Assuming the 30 June 2022 exchange rates remain stable until end of 2022, 2022 impact¹ is expected to be (%p): 0.92 0.92 0.93 0.94 0.98 0.97 0.96 0.96 0.96 0.96 0.96 0.96 Q1 HY Sep FY YTD Monthly avg fx rates 2022 Fx rates 30th June 2022 Sales -1 0 -1 -1 CHF / EUR Core -5% -6% -6% -6% operating 0 -1 1.09 1.09 profit 1.09 1.08 + 1.04 1.03 Core EPS 0 -1 1.02 1.01 1.04 1.05 1.02 1.02 1.04 1.03 1.00 1.00 1.00 1.00 1.00 1.00 Monthly avg fx rates 2022 Fx rates 30th June 2022 1 On group growth rates 69

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