Roche Pharmaceutical Development and Sales Overview

PRED infectious diseases development programs Molecule Indication Phase # of patients Infectious Diseases Roche Status CT Identifier TLR7 agonist (3) (RG7854) Chronic hepatitis B FPI Q4 2016 150 TLR7 agonist (3)/ siRNA/ PDL1 LNA Chronic hepatitis B || 275 FPI Q3 2020 (RG7854/RG6346/RG6084) Data presented at APASL 2019 NCT02956850 NCT04225715 (PIRANGA) FPI Q1 2019 PDL1 LNA (RG6084) Chronic hepatitis B 35 Part la: completed Part lb: initiated Abx MCP (RG6006) A. baumannii infections | 204 FPI Q4 2020 NCT04605718 Abx MCP-antibiotic macrocyclic peptide 135

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