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Investor Presentation

107 Investor presentation First six months of 2022 International Operations at a glance. Novo NordiskⓇ Diabetes trend Million 600 400 200 0 11 487 2021 587 2030 Population with diabetes Diabetes growth rate DKK 19% billion 250 17% Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales First half of 2022 Sales (mDKK) Growth² 80% Total GLP-13 12,013 53% Long-acting insulin4 6,020 4% 200 34.0%¹ 60% Premix insulin5 5,242 -8% Fast-acting insulin 5,689 0% 150 Insulin Human insulin 3,375 -18% 720 4.7%¹ 40% Total insulin 20,326 -5% 100 Other Diabetes care? 1,331 -11% 20% Diabetes care 33,670 10% 50 7.4%1 OAD Obesity care 2,480 60% 0 May 2045 2017 0% Diabetes & Obesity 36,150 12% May 2022 care Rare disease⁹ 6,453 1% GLP-1 MS -Insulin MS -OAD MS Total 42,603 10% Diabetes trend estimates based on the following International Diabetes Foundation defined regions: Africa, Europe, Middle East and North Africa, South and Central America, South East Asia and Western Pacific; Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021 1 CAGR calculated for 5-year period; Competitor insulin value market shares, as of May 2022: Novo Nordisk 50%, Sanofi 27% and Eli Lilly 14%; Competitor GLP-1 value market shares, as of May 2022: Novo Nordisk 60%, Eli Lilly 37% and AstraZeneca 2%; OAD: Oral anti-diabetic; MS: Market share; Source: IQVIA MAT, May 2022 value figures 2 At Constant exchange rates; 3 Comprises Victoza®, OzempicⓇ, and RybelsusⓇ; 4 Comprises Tresiba®, XultophyⓇ and LevemirⓇ: 5 Comprises RyzodegⓇ and NovoMixⓇ: 6 Comprises FiaspⓇ and NovoRapidⓇ; 7 Comprises Novo NormⓇ and needles; 8 Obesity care comprises SaxendaⓇ and Wegovy®: 9 Comprises primarily NovoSeven®, Novo Eight® NovoThirteen®, Refixia®, Esperoct®, Norditropin, Vagifem® and Activelle® Source: Quarterly company announcement
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