TROPION-Lung01 Study Design and Baseline demographics

Progression-Free Survival PFS by BICR: primary endpoint Probability of PFS 1.0 0.9- 0.8 0.7 0.6- 0.5 0.4 0.3 0.2- 0.1 0. 0 Number at risk Dato-DXd 365 ICC 367 365 Dato-DXd (n=365) ICC (n=367) 3 249 205 38.5% 6 53.3% Dato-DXd ICC Median PFS, months (95% CI) 6.9 (5.7-7.4) 4.9 (4.2-5.5) HR (95% CI) 0.63 (0.52-0.76) <0.0001 P-value 37.5% 25.5% I 18.7% I 14.6% i I + 9 12 15 Time from randomisation (months) 158 93 66 26 15 8 4 Cl, confidence interval; HR, hazard ratio PFS by investigator assessment: Median 6.9 vs 4.5 months; HR 0.64 (95% CI 0.53-0.76) Daiichi-Sankyo 30 30

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