Investor Presentaiton

NON-GAAP OPERATING MARGIN % OF REVENUE Lilly 30.0% 29.0% 28.0% 27.0% 26.0% 25.0% 24.0% Q1 Q2 Q3 2021 MOVING ANNUAL TOTAL 70 Q4 Q1 00 Q2 03 Q3 Q4 Q1 Q2 2022 2023 Individual Quarter 23.1% 29.1% 27.9% 27.0% 33.4% 20.5% 28.9% 27.4% 23.3% 27.1% Op. Margin % of Revenue: Op. Margin impact of -4.6% -0.6% -2.6% -5.5% -2.1% -6.8% -0.9% -3.3% -1.5% -1.2% Acquired IPR&D Charges The line in the graph is a moving annual total (i.e. trailing 4 quarters) while the row of numbers is from specific quarters. Not for promotional use 2023 Q2 EARNINGS 23

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