Investor Presentaiton

Oxidation of Various Amines by Fungal Amine Oxidase N + 02 2 + H,O, * NH3 NH2 Histamine Imidazole acetaldehyde Relative Relative Substrate Substrate rate rate Monoamine Monoamine Ethylamine 4.0 Benzylamine 100* n-Propylamine 108.0 Phenethylamine 150.6 n-Butylamine 195.2 Diamine n-Amylamine 194.8 Ethylenediamine 0 n-Hexylamine 194.5 Propylenediamine 0 Tyramine 75.1 Putrescine 13.2 Tryptamine 28.8 Cadaverine 13.6 Epinephrine 0 Hexylenediamine 13.9 Norepinephrine 67.3 Polyamine Serotonin 42.0 Spermine 0 Agmatine 89.0 Spermidine 0 Histamine 110.5

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