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Investor Presentaiton

Syapse-Company Overview Market Segment: Headquarters: CEO: COMPANY OVERVIEW Precision Medicine San Francisco, CA Ken Tarkoff • Multi-sided platform creating a data network effect in order to improve the way cancer and other diseases are treated Origin: Capital: Ownership: syapse SUMMARY June 2014 $25.0M 11% Primary/9% Fully Diluted Series B, Series C, Series D, Series E, Series F, Series G (February 2021) Amgen Ventures, Ascension Ventures, • Health systems contribute clinical and other data to the platform and receive clinical and business insights • Pharma, on the other side of the platform, purchases insights and delivers information back to health systems Financing Rounds: Syapse collects and networks data from siloed hospital and laboratory enterprise systems (Syapse Network) allows the Company to provide solutions for pharma including real world evidence generation, identification of patients for clinical trials and hub services Other Investors: • Ecosystem partnerships with Pfizer, Amgen, others TBA Board Member: Gary Kurtzman Intermountain Healthcare Innovation Fund, Merck GHIF, Medidata Ventures, Northpond Ventures, Revelation Partners, Social Capital THESIS REVENUE MODEL • Syapse is initially focused on oncology, opportunity to leverage the platform to other disease verticals anticipated in 2020 and beyond Scalability allows targeting of large community health systems (50% of oncology pts in U.S) and ex-U.S, expansion $9B U.S./$15B Global market opp. from pharma partnerships and $250M U.S./$1B Global market opp. from health systems in oncology Syapse contracts with pharma and other ecosystem relationships via multi-year license agreements for products across RWE, clinical trial, regulatory, and commercial use cases. COMPETITORS Flatiron Health, Cota, Tempus Health, Concerto G www.safeguard.com © 2021 Safeguard Scientifics, Inc. All rights reserved. SFE LISTED NYSE 23
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