3M Results Presentation Deck

Updating estimates to reflect FX and macroeconomic environment Adjusted earnings per share $10.30 to $10.80 Adjusted free cash flow conversion 90% to 100% Updating full-year expectations: Organic sales growth 1.5% to 3.5% 1 FX impact on total sales growth: • -4% vs. -1% previously U.S. dollar at a 20-year high ● 2 Organic sales growth: ● 1.5% to 3.5% vs. 2% to 5% previously Ongoing macroeconomic uncertainty Macro: IPI & GDP: ~3%; most end-markets remain strong Monitoring Greater China region COVID-related lockdowns Geopolitical uncertainty due to Russia/Ukraine conflict ● End-markets/supply chain/inflationary impacts: • Auto OEM builds up ~5% YoY; semiconductor and supply chain challenges along with geopolitical impacts constraining pace of build rate U.S. healthcare elective procedure volumes ~95% to 100%; U.S. oral care volumes at ~90% by year-end, impacted by COVID-related staff shortages and patient cancellations Weakening consumer electronics demand, particularly smartphones, tablets and TVs Monitoring consumer sentiment and spending trends Expecting supply chain challenges to persist for foreseeable future Navigating inflationary pressures through disciplined price actions; expect raw material & logistics full-year headwind of $750M to $850M YOY Note: Above guidance does not include the impact of pending separation of Food Safety business via Reverse Morris Trust (RMT) transaction with Neogen 2022 Q2 Earnings - July 26, 2022. All rights reserved. 3M 23

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