Genelux Investor Presentation Deck

CD8+ T-cells: Infiltrating Lymphocytes are Prognostic for Response/Survival Induced tration of CD8+ cells into Tumors Shift of CD8+ cells into Endogenous TILS (intra- tumoral and stromal) are very low in ovarian cancer epithelial tissue Pre-Olvi-Vec GENELUX Post-Olvi-Vec (prior to subsequent chemotherapy) Baseline Screening CD4 CD4 Inside Post Outside Tumor Treatment R 8 15 4 100μm 10 5 100μm -200 200- 8 100 -200 Pt# 15A-16 CD4+ CD8 Pt# 15A-16 -100 CD8 -100 HALO™ Infiltration Histogram CD8+ densities around interface 42 1:00 Distance from interface [um] 100μm 100 Distance from Interface [um] CD8+ 100μm- HALO™ Infiltration Histogram CD8+ densities around interface 705 146 14 200 Inside Tumor 200 CD4 CD4 Outside Tumor CD8+ permm² CD8+per mm² 40 30 10 100μm CD4+ 100μm -200 150- 0- -200 Pt# 15A-18 Pt# -100 CD8 I CD8 1:00 Distance from Interface [um] -100 Pt# 15A-18 HALO™ Infiltration Histogram CD8+ densities around interface 126 45 100μm 100 Distance from Interface [um] CD8+ 100μm HALO™ Infiltration Histogram CD8+ densities around interface 494 109 200 Inside Tumor 200 CD4 CD4 Outside Tumor 4 100μm CD4+ 04 30 -200 4100μm 01 -200 15A-23 -100 CD8 O CD8 Pt# 15A-23 HALO™ Infiltration Histogram CD8+ densities around interface 107 69 1:00 Distance from Interface [um] 100μm 1:00 CD8+ Distance from Interface [um] 100μm HALO™ Infiltration Histogram CD8+ densities pround interface: 135 28 200 200 36

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