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Investor Presentation

PHYTOCANNABINOID Competitive Landscape: Peers and Competitors COMPANIES X Not competitors X 12 X Focused on CBD or THC-based CB1 agonists for CNS GW Pharma: Epidiolex™ (CBD) approved 2018 Insys: Syndros™ (THC) approved 2017 Systemic Sclerosis • Roche (Tocilizumab IL-6 receptor blocker: Ph 3 missed primary outcome) Bayer (Riociguat, PAH drug: Ph 2 missed primary outcome) BI (Nintedanib, IPF drug: Ongoing Ph 3 for ILD in SSc) BMS (Abatacept, RA drug: Ph 2 missed primary outcome) GSK (GSK2330811 anti-oncostatin M Mab: Ph 2) ● ● ● Dermatomyositis Idera (TLR target: Ph 2 missed primary outcome) Pfizer (PF-06823859 interferon beta inhibitor: Ph 2a) Inflammation in CF Celtaxys (acebilustat LTA4 hydrolase inhibitor: Ph 2 missed primary outcome) CFTR products are not direct competitors (Vertex) ● ● ●
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