Investor Presentaiton
Innovative R&D - Co-development
Co-development cases: Deepen international collaboration, accessing cutting edge technologies
Yi Kai Da (Axicabtagene Ciloleucel Injection) became the first CAR-T cell therapy product approved for launch in China in June 2021
Indication Expansion
Significant needs
i potential as moving from
third-line treatment to
second-line treatment
•
Commercialization
~ 90,000 new NHL patients in China each year, 10,000 patients with third-line treatment*
LBCL third-line therapy:
Yi Kai Da became the first CAR-T cell therapy
product approved for launch in China in June 2021
Yescarta launched in the U.S. in October 2017
LBCL second-line therapy:
Yescarta became the world's first CAR-T cell
therapy product approved by FDA for LBCL second-
line therapy
Yi Kai Da was approved for LBCL second-line
therapy clinical trials by NMPA in August 2022
Yescarta (ZUMA-1):
5yrs OS 42.6%; for CR patients, 5yrs OS 64.4%
Multicenter Clinical Trial in China for Bridging
Study:
ORR 79.2%
Yescarta (ZUMA-7):
Yescarta vs. SOC in second-line therapy of r/r
DLBCL (Median follow-up: 24.9mths)
ORR: 83% vs. 50%; CR: 65% vs. 32%
Median EPS: 8.3mths vs. 2mths
Established nearly 100 certified treatment centers and 10,000 m² GMP commercial manufacturing facility by the end of July 2022
Exploring diversified payment methods, including commercial insurance and citizen insurance. Yi Kai Da is included in over 50 commercial
insurances and 44 citizen insurances by the end of July 2022.
Product Pipeline
The second indication r/r iNHL was granted Breakthrough Therapy Designation by the NMPA in August 2021 and the clinical trials in China are
under process
FDA approved Tecartus (brexucabtagene autoleucel) for the treatment of adult patients with relapsed/refractory mantle cell lymphoma (MCL) in
July 2020; FKC889 for MCL is in the clinical stage in China
Note*: source from Global Cancer Statistics 2018
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