Ocuphire Pharma Results Presentation Deck
RM
16
Secondary Endpoint: Mean Pupil Diameter Over Time by Mydriatic Agent
Nyxol Reduced Pupil Diameter With All Mydriatic Agents; More Rapidly with Phenylephrine as Expected
Pupil Diameter (mm)
9
8
LO
4
3
Mydriatic
L
-1
1
Max pupil dilation,
Treatment p<0.0001
T
Phenylephrine
p<0.0001
-Nyxol n=56
T
p<0.0001
I
I
p<0.0001 p<0.0001
MIRA-2 Phase 3 Trial
Study Eye, mITT Population
Placebo n=55
4
0 0.5 1 1.5 2
3
Time Post-Treatment with Nyxol/Placebo
(Hours)
p<0.0001
H
Source: MIRA-2 TLR table #14.2.2.3 (mITT). Standard Error bars are shown.
6
Pupil Diameter (mm)
9
8
4
3
±
Max pupil dilation,
Treatment
Mydriatic
Tropicamide or Paremyd
p<0.0001
p<0.0001 X
p<0.0001
-Nyxol n=38
-1 0 0.5 1 1.5 2
T
p<0.0001
p<0.0001
Placebo n=36
3
4
Time Post-Treatment with Nyxol/Placebo
(Hours)
p<0.0001
+4
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