First Quarter 2018 Investor Presentation

Investor Presentation First three months of 2018 Slide 43 Stable global insulin volume growth Regional insulin volume growth Region Europe North America Region China Region J&K 30% 25% 20% 15% 10% Regional insulin volume market split Region Europe Region J&K Region AAMEO North America Region LATAM Region China World 100% 80% 60% 40% 5% 0% Feb 2013 20% 3% 0% Feb 2018 Feb 2013 Reg: Region; J&K: Japan & Korea; AAMEO: Africa, Asia, Middle-East and Oceania; LATAM: Latin America Note: Data is sensitive to changes in IQVIA data collection and reporting methodology Source: IQVIA monthly MAT Feb, 2018 volume figures changing diabetes® Region AAMEO Region LATAM 3% 3% 10% 21% 33% 30% Feb 2018 Reg: Region; J&K: Japan & Korea; AAMEO: Africa, Asia, Middle-East and Oceania; LATAM: Latin America Note: Data is sensitive to changes in IQVIA data collection and reporting methodology Source: IQVIA monthly MAT Feb, 2018 volume figures novo nordisk

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